Daily tablet, orforglipron
Foundayo pill for weight loss
Foundayo is a once-daily orforglipron tablet. No needles, no fridge and no empty-stomach rule. Take your tablet whenever suits your day.
Prices to be confirmed
Start with the Foundayo pillThe planned service requires a clinical assessment before any treatment can be supplied. The secure assessment is not connected in this preview. Read how assessment works or prepare a discussion checklist. Provider details, prices and delivery arrangements must be confirmed before launch.
- UK prescriber review
- Dispensing arrangements to be confirmed
- Delivery arrangements to be confirmed
In short: Foundayo (orforglipron) is a once-daily GLP-1 tablet in six strengths from 0.8 mg to 17.2 mg, with no food or water restrictions. Average weight loss was 11.2% at 72 weeks on the top dose in the ATTAIN-1 trial. Aero’s prices are not yet confirmed.
How Foundayo works
Orforglipron is a small-molecule GLP-1 receptor agonist. Semaglutide and tirzepatide are peptides, fragile proteins needing injection or careful formulation. Orforglipron is built like a conventional drug, so the tablet survives digestion.
The chemistry brings convenience: no fridge, no fasting window and no 30-minute wait before breakfast.
In ATTAIN-1, the largest obesity trial of orforglipron, the highest dose produced an average loss of 11.2% of body weight over 72 weeks, or 12.4% among people who stayed on treatment, alongside diet and activity support. The figure trails Mounjaro and sits ahead of older daily treatments.
Foundayo doses and prices
Treatment begins at 0.8 mg daily. Each step up comes after at least 30 days where tolerated, through 2.5 mg, 5.5 mg, 9 mg and 14.5 mg to a maximum of 17.2 mg. Many people settle where appetite control and comfort balance.
| Dose | Price |
|---|---|
| 0.8 mg starter dose | To be confirmed |
| 2.5 mg, 5.5 mg, 9 mg, 14.5 mg and 17.2 mg | Price rises with dose and is confirmed before you pay |
The ATTAIN trials used capsules labelled 1 mg to 36 mg. The licensed Foundayo tablets deliver equivalent doses at 0.8 mg to 17.2 mg. Your pack and your prescriber use the tablet strengths.
What the trials found
ATTAIN-1 tested orforglipron 36 mg capsule (equivalent to the 17.2 mg tablet) in 3,127 adults for 72 weeks, alongside diet and activity support.
11.2%
average weight loss, counting every participant. The placebo group averaged 2.1%.
Other trials
- ATTAIN-2 (obesity with type 2 diabetes). 72 weeks. Mean weight change (efficacy estimand, UK SmPC) was -5.5% with 6 mg, -7.8% with 12 mg and -10.5% with 36 mg versus -2.2% with placebo. 72.8% versus 24.4% lost at least 5% on the top dose, 50.1% versus 7.0% at least 10%. HbA1c fell by 1.3, 1.6 and 1.8 percentage points versus 0.1.
- ATTAIN-MAINTAIN (maintenance after injections). 376 adults who finished 72 weeks of tirzepatide or semaglutide in SURMOUNT-5 were randomised to orforglipron or placebo for 52 weeks. After tirzepatide, orforglipron kept 74.7% of the earlier weight loss versus 49.2% with placebo. After semaglutide, 79.3% versus 37.6%. Average regain on orforglipron was about 5 kg after tirzepatide and about 1 kg after semaglutide.
Side effect rates in trials
| Effect | Rate | Dose |
|---|---|---|
| Nausea | 33.7% | 36 mg capsule (17.2 mg tablet) |
| Constipation | 25.4% | 36 mg capsule (17.2 mg tablet) |
| Vomiting | 24% | 36 mg capsule (17.2 mg tablet) |
| Diarrhoea | 23.1% | 36 mg capsule (17.2 mg tablet) |
| Abdominal pain | 14% | 17.2 mg tablet |
| Dyspepsia (indigestion) | 13% | 17.2 mg tablet |
| Any gastrointestinal disorder | 68.7% | 36 mg capsule (17.2 mg tablet) |
| Stopped treatment because of an adverse event | 10.3% | 36 mg capsule (17.2 mg tablet) |
Main trial: Wharton S, Aronne LJ, Stefanski A, et al. Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment. N Engl J Med, published online 16 September 2025. Individual results vary, and no result is promised.
Questions about support for the Foundayo pill
Aero’s treatment prices and service inclusions will be confirmed before booking opens. Ask which prescribing, dispensing, delivery and follow-up costs are included in your quote.
- Before treatment begins, the prescribing clinician’s identity and professional registration must be clear. Aero’s named prescriber details will be published before booking opens.
- Agree a follow-up schedule with your prescriber, including how you report progress and side effects and who decides whether a dose should change.
Ask how to contact your clinical team
Questions about side effects, injecting or travel go to the pharmacy team who dispense your medicine. Clinical support hours and response times will be confirmed before the service launches.
What support includesSide effect help when you need help
You get practical steps for nausea, constipation and reflux, plus the warning signs needing urgent care.
Side effects and problemsFood, movement and sleep guidance
Nine guides cover protein, hydration, exercise and sleep, so you keep muscle while you lose weight.
Read the guides- Ask how maintenance care will be reviewed and priced. Aero’s longer-term service arrangements will be confirmed before booking opens.
Who Foundayo suits
- People who want to avoid needles entirely.
- Anyone who found the Wegovy pill fasting rule unworkable, such as shift workers and early commuters.
- Frequent travellers. Room-temperature storage and no timing rules make Foundayo the simplest option abroad.
- People who want a moderate, steady pace of loss.
Side effects and safety
Common and usually short-lived
Nausea, constipation, diarrhoea and reflux, concentrated around dose increases. For most people they settle within a couple of weeks.
Full side effects guideGet urgent help
Severe stomach pain reaching your back, facial swelling, or vomiting so severe you keep no fluids down. Call 999 or go to A&E. For other concerns call 111.
Tell your prescriber about
Diabetes medicines, other regular medicines, past gallbladder or pancreas problems, and any pregnancy plans.
Report any suspected side effect through the MHRA Yellow Card scheme. Read the patient leaflet in your pack before your first dose.
Safety information for all four medicinesWhen to get urgent help
Who can start the Foundayo pill
Your prescriber makes the final decision after your health check.
Usually suitable
- Aged 18 to 75
- BMI of 30 or above
- BMI of 27 or above with a weight-related condition, such as high blood pressure
- Lower BMI thresholds can apply for some ethnic backgrounds
Not suitable
- Pregnant, breastfeeding or trying to conceive
- History of pancreatitis
- Personal or family history of medullary thyroid cancer or MEN2
- Type 1 diabetes, or a current eating disorder
Foundayo pill key facts
The main points from the UK product information and the main trial, in one table.
| Detail | Information |
|---|---|
| Active ingredient | Orforglipron |
| Medicine type | Oral non-peptide (small molecule) GLP-1 receptor agonist |
| Made by | Eli Lilly |
| Form | Film-coated tablet |
| How often | Once daily, at any time of day, with or without food, no water restriction |
| Dose range | 0.8 mg to 17.2 mg |
| Dose steps | 6 strengths, at least 30 days each |
| Highest dose | 17.2 mg once daily |
| Main trial | ATTAIN-1, 3,127 people, 72 weeks |
| Average loss in the main trial | 11.2% on 17.2 mg, against 2.1% on placebo |
| Storage | Keep in the original pack, away from light |
| Missed dose | Take when you remember. One tablet a day at most |
| The contraceptive pill | Can reduce the effect. Follow the leaflet on barrier or non-oral methods |
| Stop before a planned pregnancy | At least 3 weeks |
| Legal status | Prescription only medicine |
| On the NHS | Not available on the NHS |
| Price at Aero Clinic | To be confirmed |
Foundayo pill questions
How much does Foundayo cost?
Aero’s treatment prices are not yet confirmed. Before paying, ask for the total price, pack quantity, prescribing fees, dispensing and delivery charges, and follow-up costs. Use your provider’s written quote in the cost planner.
Is Foundayo as strong as Mounjaro?
Not on headline trial averages. The highest Foundayo dose averaged 11.2% loss against 20.9% for Mounjaro 15 mg. Many people trade some potency for a needle-free daily tablet with no food rules. Read Foundayo vs Mounjaro.
Do I take Foundayo with food?
Foundayo can be taken with or without food. The UK authorisation does not require timing meals or water around the dose. Follow your prescription and check the MHRA’s information alongside the leaflet supplied with your tablets.
Can I switch from an injection to Foundayo?
A switch requires an individual prescribing decision. Your current medicine, recent doses, side effects and medical history all matter. Ask your prescriber to confirm the stopping and starting instructions; do not combine treatments or convert doses yourself.
Foundayo pill guides
Other plans
Clinical governance
Awaiting clinical provider details
The dispensing pharmacy, GPhC registration number and Superintendent Pharmacist will be named here once confirmed. A UK prescriber reviews every order before any medicine is supplied.
Page information
- Summary
- Explore the Foundayo orforglipron guide: tablet routines, doses, trial evidence and side effects. Aero prices and prescribing arrangements remain pending.
- Publisher
- Aero Clinic, operated by AERO HEALTHCARE LTD.
- Editorial update
- Clinical review
- Pending. An editorial update is not a clinical sign-off.
Cite as: Foundayo pill for weight loss, Aero Clinic (https://www.cagri.co.uk), AERO HEALTHCARE LTD. https://www.cagri.co.uk/foundayo. Editorial update: 4 November 2026. Clinical review pending.